Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 17/20 | 0.59 |
| ▸ | HTR2A | P28223 | 16/20 | 0.59 |
| ▸ | DRD2 | P14416 | 9/20 | 0.55 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.53 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.53 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.53 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.53 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL229123 | 0.97 | HTR2A (0.54) | DRD3HTR2ADRD2PRKAB2PRKAG1 | |
| SCHEMBL228592 | 0.95 | DRD3 (0.64) | DRD3HTR2ADRD2PRKAB2PRKAG1 | |
| SCHEMBL228055 | 0.87 | HTR2A (0.65) | DRD3HTR2ADRD2 | |
| SCHEMBL230299 | 0.87 | HTR2A (0.55) | DRD3HTR2ADRD2PRKAB2PRKAG1 | |
| SCHEMBL229741 | 0.87 | HTR2A (0.65) | DRD3HTR2ADRD2 | |
| SCHEMBL227201 | 0.87 | DRD3 (0.60) | DRD3HTR2ADRD2 | |
| SCHEMBL251440 | 0.85 | HTR2A (0.65) | DRD3HTR2ADRD2 | |
| SCHEMBL228853 | 0.84 | HTR2A (0.52) | DRD3HTR2ADRD2PRKAB2PRKAG1 | |
| SCHEMBL230363 | 0.83 | DRD2 (0.62) | DRD3HTR2ADRD2 | |
| SCHEMBL228637 | 0.82 | HTR2A (0.64) | DRD3HTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987019-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS 5HT2/D3 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-05 | — | — | EP | claimed |
| WO-2007093540-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS 5HT2/D3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-23 | — | — | WO | claimed |
| EP-1987019-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS 5HT2/D3 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093540-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS 5HT2/D3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-23 | — | — | WO | disclosed |