Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5003303 | 0.87 | MAPT (0.48) | SMN1; SMN2KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL4994712 | 0.86 | MAOB (0.44) | SMN1; SMN2KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL4992025 | 0.84 | NPC1 (0.47) | SMN1; SMN2KMT2AMAPTALDH1A1NPSR1 | |
| SCHEMBL4987334 | 0.82 | NPC1 (0.45) | SMN1; SMN2KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL4996877 | 0.82 | NPC1 (0.45) | SMN1; SMN2KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL5003385 | 0.81 | CHEK1 (0.52) | SMN1; SMN2KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL4995201 | 0.78 | MAPT (0.44) | SMN1; SMN2KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL4994249 | 0.76 | CHEK1 (0.56) | SMN1; SMN2KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL4993330 | 0.75 | CHEK1 (0.57) | SMN1; SMN2KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL4997015 | 0.74 | NPY2R (0.42) | KDM4EMAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | SMN1; SMN2 896/4885KMT2A 4601/4885KDM4E 3445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.