Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4991797 | 0.85 | CHEK1 (0.46) | CHEK1KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL4993330 | 0.85 | CHEK1 (0.57) | CHEK1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL5000885 | 0.84 | NPC1 (0.47) | CHEK1HRH3KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4994249 | 0.84 | CHEK1 (0.56) | CHEK1KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL4997514 | 0.84 | MAPT (0.50) | CHEK1SMN1; SMN2KDM4EMAPTALDH1A1 | |
| SCHEMBL5003418 | 0.84 | CHEK1 (0.55) | CHEK1HRH3KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4997671 | 0.84 | KDM4E (0.45) | CHEK1HRH3KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4987763 | 0.83 | CYP11B1 (0.56) | CHEK1KMT2ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL5000654 | 0.83 | CHEK1 (0.54) | CHEK1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL4997072 | 0.83 | CHEK1 (0.54) | CHEK1KMT2AMEN1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | CHEK1 1668/4885HRH3 3459/4885KMT2A 4601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.