Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | FPR2 | P25090 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12334098 | 0.91 | MAPT (0.57) | MAPTHRH4KMT2AMEN1TP53 | |
| SCHEMBL27836005 | 0.86 | MAPT (0.70) | MAPTHRH4KMT2AMEN1FPR2 | |
| SCHEMBL27836006 | 0.84 | MAPT (0.62) | MAPTHRH4KMT2AMEN1FPR2 | |
| SCHEMBL4999923 | 0.84 | HRH4 (0.65) | MAPTHRH4KMT2AMEN1TP53 | |
| SCHEMBL2351433 | 0.84 | HRH4 (0.78) | MAPTHRH4KMT2AMEN1NPC1 | |
| SCHEMBL2347252 | 0.82 | HRH4 (0.76) | MAPTHRH4KMT2AMEN1NPC1 | |
| SCHEMBL29991093 | 0.81 | HRH4 (0.62) | MAPTHRH4KMT2AMEN1FPR2 | |
| SCHEMBL21225313 | 0.81 | HRH4 (0.62) | MAPTHRH4KMT2AMEN1FPR2 | |
| SCHEMBL21225315 | 0.81 | HRH4 (0.62) | MAPTHRH4KMT2AMEN1FPR2 | |
| SCHEMBL4338439 | 0.81 | HRH4 (0.65) | MAPTHRH4KMT2AMEN1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221114-A1 | 2-(Cyclic Aminocarbonyl) Indoline Derivative and Medicinal Composition Containing the Same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2008-09-11 | — | — | US | disclosed |
| CN-101103019-A | 2- (Cyclic aminocarbonyl) indoline derivative and pharmaceutical composition containing same | DAINIPPON SUMITOMO PHARMA CO (JP) | 2008-01-09 | — | — | CN | disclosed |
| EP-1840126-A1 | 2-(CYCLIC AMINOCARBONYL)INDOLINE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2007-10-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221114-A1 | 2-(Cyclic Aminocarbonyl) Indoline Derivative and Medicinal Composition Containing the Same | CYP11B2, CYP11B1, GRIN2A | MAPT 549/4885HRH4 138/4885KMT2A 1437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.