SCHEMBL5000897

SCHEMBL5000897

O=C(O)C(CP(=O)(O)O)=C(Cl)Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.48
LMNA P02545 1/20 0.48
HPGD P15428 1/20 0.48
TSHR P16473 1/20 0.48
BLM P54132 1/20 0.48
KMT2A Q03164 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
ENO1 P06733 1/20 0.37
PGK1 P00558 1/20 0.36
PGK2 P07205 1/20 0.36
ACE P12821 1/20 0.32
CA2 P00918 1/20 0.31
CA4 P22748 1/20 0.31
GRIN2D O15399 1/20 0.31
GRIN3B O60391 1/20 0.31
GRIN1 Q05586 1/20 0.31
GRIN2A Q12879 1/20 0.31
GRIN2B Q13224 1/20 0.31
GRIN2C Q14957 1/20 0.31
GRIN3A Q8TCU5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30520176 0.77 MEN1 (0.50) MEN1LMNAHPGDTSHRBLM
SCHEMBL1003389 0.73
SCHEMBL29258993 0.73
SCHEMBL27561509 0.71 MEN1 (0.44) MEN1LMNAHPGDTSHRBLM
SCHEMBL4105544 0.69
SCHEMBL50366 0.67 MEN1 (0.58) MEN1LMNAHPGDTSHRBLM
Fosfonet SCHEMBL15612 0.66
SCHEMBL3903608 0.65 MEN1 (0.42) MEN1LMNAHPGDTSHRBLM
SCHEMBL5962754 0.65 MEN1 (0.42) MEN1LMNAHPGDTSHRBLM
Fosfonet SCHEMBL11026013 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3681504-B1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ICAGEN INC (US) 2023-08-23 EP disclosed
US-11573224-B2 Methods of detection using X-ray fluorescence ICAGEN, LLC (US) 2023-02-07 US disclosed
US-11446398-B2 Regulated biocircuit systems OBSIDIAN THERAPEUTICS, INC. (US) 2022-09-20 US disclosed
US-20210254056-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION 2021-08-19 US disclosed
US-10877035-B2 Advanced drug development and manufacturing ICAGEN, LLC (US) 2020-12-29 US disclosed
US-20200278346-A1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ADJACENT ACQUISITION CO., LLC 2020-09-03 US disclosed
EP-3681504-A1 METHODS OF DETECTION USING X-RAY FLUORESCENCE Icagen, Inc. (US) 2020-07-22 EP disclosed
EP-2797417-B1 SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS HEINRICH HEINE UNIV DUESSELDORF (DE) 2019-07-31 EP disclosed
US-20190192691-A1 REGULATED BIOCIRCUIT SYSTEMS OBSIDIAN THERAPEUTICS, INC. 2019-06-27 US disclosed
WO-2019055754-A1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ICAGEN, INC. (US) 2019-03-21 WO disclosed
CN-104114024-A Selective inhibition of phosphoenolpyruvate carboxylases of C4 plants UNIV DUESSELDORF H HEINE 2014-10-22 CN disclosed
WO-2014111448-A1 SELECTIVE INHIBITION OF C4-PEP CARBOXYLASES HEINRICH HEINE UNIVERSITÄT DÜSSELDORF (DE) 2014-07-24 WO disclosed
WO-2013093007-A1 SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS HEINRICH HEINE UNIVERSITÄT DÜSSELDORF (DE) 2013-06-27 WO disclosed
EP-2511844-A2 Advanced drug development and manufacturing Los Alamos National Security, LLC (US) 2012-10-17 EP disclosed
EP-2084519-B1 X-RAY FLUORESCENCE ANALYSIS METHOD LOS ALAMOS NAT SECURITY LLC (US) 2012-08-01 EP disclosed
US-20080220441-A1 Advanced drug development and manufacturing THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2008-09-11 US disclosed
EP-1071810-A4 ASSAY FOR SCREENING INHIBITORS OF C4 PLANT ENZYMES AUSTRALIAN INST MARINE SCIENCE (AU) 2005-11-23 EP disclosed
US-6500632-B1 AN ASSAY TO SCREEN POTENTIAL INHIBITORS OF THE C.SUB.4 ACID CYCLE IN PLANTS. THE ASSAY INVOLVES TESTING INHIBITION OF C.SUB.4 ENZYMES BY INCUBATING A MIXTURE THAT INCLUDES PYRUVATE ORTHOPHOSPHATE DIKINASE, PHOSPHOENOLPYRUVATE AUSTRALIAN INSTITUTE OF MARINE SCIENCE (AU) 2002-12-31 US disclosed
EP-1071810-A1 ASSAY FOR SCREENING INHIBITORS OF C4 PLANT ENZYMES Australian Institute of Marine Science (AU) 2001-01-31 EP disclosed
WO-1999054495-A1 ASSAY FOR SCREENING INHIBITORS OF C4 PLANT ENZYMES AUSTRALIAN INSTITUTE OF MARINE SCIENCE (AU) 1999-10-28 WO disclosed