Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 16/20 | 0.64 |
| ▸ | HSP90AB1 | P08238 | 16/20 | 0.64 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.51 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5001232 | 0.99 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1HSP90B1TRAP1OPRM1 | |
| SCHEMBL5005184 | 0.91 | HSP90AB1 (0.66) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL5009954 | 0.90 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL5009955 | 0.90 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL5005042 | 0.90 | HSP90AB1 (0.66) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL5001466 | 0.89 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL5009862 | 0.87 | HSP90AB1 (0.47) | HSP90AA1HSP90AB1OPRM1 | |
| SCHEMBL5004689 | 0.85 | HSP90AB1 (0.47) | HSP90AA1HSP90AB1OPRM1 | |
| SCHEMBL5001208 | 0.85 | HSP90AB1 (0.76) | HSP90AA1HSP90AB1HSP90B1TRAP1OPRM1 | |
| SCHEMBL3626270 | 0.85 | HSP90AB1 (0.76) | HSP90AA1HSP90AB1HSP90B1TRAP1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269193-A1 | Tetrahydroindole and Tetrahydroindazole Derivatives | SERENEX, INC. | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269193-A1 | Tetrahydroindole and Tetrahydroindazole Derivatives | HSF1, HSP90AB1, TPH1 | HSP90AA1 4/4885HSP90AB1 2/4885HSP90B1 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.