Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 6/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | F12 | P00748 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4993330 | 0.89 | CHEK1 (0.57) | CHEK1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4994249 | 0.88 | CHEK1 (0.56) | CHEK1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL5002823 | 0.88 | CHEK1 (0.67) | CHEK1ROCK2ROCK1PIM2F12 | |
| SCHEMBL4997769 | 0.87 | PIM2 (0.52) | CHEK1NPC1RAB9ASMN1; SMN2PIM2 | |
| SCHEMBL5000654 | 0.86 | CHEK1 (0.54) | CHEK1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4997072 | 0.86 | CHEK1 (0.54) | CHEK1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL5003385 | 0.84 | CHEK1 (0.52) | CHEK1HRH3NPC1RAB9AMAPT | |
| SCHEMBL4997188 | 0.83 | HRH3 (0.53) | HRH3NPC1RAB9AMAPTLMNA | |
| SCHEMBL4997459 | 0.83 | CHEK1 (0.45) | CHEK1MAPTROCK2ROCK1PIM2 | |
| SCHEMBL5000847 | 0.83 | CHEK1 (0.46) | CHEK1NPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | CHEK1 1668/4885HRH3 3459/4885NPC1 2008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.