Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.83 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 4/20 | 0.58 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009705 | 0.92 | BRAF (0.73) | BRAFMEN1KMT2ACSF1RKIT | |
| SCHEMBL5004904 | 0.89 | BRAF (0.76) | BRAFRAF1CYP2C9 | |
| SCHEMBL5000903 | 0.83 | BRAF (0.70) | BRAFMEN1KMT2ACSF1RHDAC6 | |
| SCHEMBL5007830 | 0.83 | MAPK14 (0.72) | BRAFMEN1KMT2ACSF1RHDAC6 | |
| SCHEMBL5007906 | 0.83 | BRAF (0.69) | BRAFMEN1KMT2ACSF1RHDAC8 | |
| SCHEMBL5007890 | 0.81 | BRAF (0.71) | BRAFRAF1CYP2C9 | |
| SCHEMBL5001022 | 0.81 | BRAF (0.64) | BRAFMEN1KMT2ARAF1NPC1 | |
| SCHEMBL5509423 | 0.80 | CSF1R (0.70) | BRAFMEN1KMT2ACSF1RHDAC6 | |
| SCHEMBL5897754 | 0.80 | BRAF (1.00) | BRAFCSF1RKITRAF1PDGFRB | |
| SCHEMBL12065267 | 0.80 | BRAF (0.62) | BRAFCSF1RKITRAF1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207616-A1 | Quinoxalines as B Baf Inhhibitors | ASTRAZENECA AB (SE) | 2008-08-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207616-A1 | Quinoxalines as B Baf Inhhibitors | BRAF, NRAS, ARAF | BRAF 1/4885MEN1 671/4885KMT2A 1967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.