Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PTPRC | P08575 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | TDP2 | O95551 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28770354 | 0.89 | HPRT1 (0.52) | ALDH1A1TDP1PTPRCLMNATSHR | |
| SCHEMBL28043433 | 0.86 | CYP19A1 (0.54) | ALDH1A1TDP1PTPRCLMNATSHR | |
| SCHEMBL30469330 | 0.83 | ALDH1A1 (0.61) | ALDH1A1TDP1LMNATSHRMAPT | |
| SCHEMBL20557569 | 0.83 | ALDH1A1 (0.61) | ALDH1A1TDP1LMNATSHRMAPT | |
| Nitrogen SCHEMBL27281424 | 0.83 | CYP19A1 (0.50) | ALDH1A1TDP1PTPRCLMNATSHR | |
| SCHEMBL5418627 | 0.82 | ALDH1A1 (0.58) | ALDH1A1TDP1LMNATSHRMAPT | |
| SCHEMBL6647084 | 0.81 | ALDH1A1 (0.57) | ALDH1A1TDP1PTPRCLMNATSHR | |
| SCHEMBL8051514 | 0.81 | ALDH1A1 (0.67) | ALDH1A1TDP1PTPRCLMNATSHR | |
| SCHEMBL5003972 | 0.80 | CYP2A6 (0.54) | ALDH1A1TDP1PTPRCLMNAMAPT | |
| SCHEMBL11564194 | 0.80 | ALDH1A1 (0.47) | ALDH1A1TDP1PTPRCLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414063-B2 | Inhibitors of Akt (protein kinase B) | ELI LILLY AND COMPANY (US) | 2008-08-19 | — | — | US | disclosed |
| CN-101076496-A | Transition metal-magnetic iron oxide nanocomposite and preparation method and application thereof | UNIV BEIJING (CN) | 2007-11-21 | — | — | CN | disclosed |
| US-20070043040-A1 | Inhibitors of akt (protein kinase b) | ELI LILLY AND COMPANY | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043040-A1 | Inhibitors of akt (protein kinase b) | AKT1, AKT2, BRAF | ALDH1A1 4411/4885TDP1 2083/4885PTPRC 507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.