SCHEMBL5006472

SCHEMBL5006472

CCCCC(C#N)CCc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CTSC P53634 1/20 0.43
SIGMAR1 Q99720 3/20 0.43
CTSS P25774 2/20 0.42
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
CNR2 P34972 1/20 0.41
KCNH2 Q12809 1/20 0.40
CTSL P07711 1/20 0.39
POLB P06746 1/20 0.39
PTGES O14684 1/20 0.39
ALOX5 P09917 1/20 0.39
PPARG P37231 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5935806 0.84 CYP1A2 (0.43) SIGMAR1CYP1A2CYP2C9CYP2C19CNR2
SCHEMBL11413506 0.84 CSNK1E (0.45) CTSCSIGMAR1CTSSCNR2CTSL
SCHEMBL8939338 0.83 TSHR (0.50)
SCHEMBL10818756 0.81 TDP1 (0.59)
SCHEMBL7289345 0.80 CTSC (0.38) CTSCCTSSCYP1A2CTSLPOLB
SCHEMBL8939339 0.79 TSHR (0.53)
SCHEMBL7293203 0.78 CTSC (0.39) CTSCCTSSCYP1A2CTSLPOLB
SCHEMBL8939308 0.78 TSHR (0.55)
SCHEMBL8939328 0.78 TSHR (0.55)
SCHEMBL8939324 0.78 TSHR (0.55)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080274879-A1 Process of producing an organic catalyst HILER GEORGE DOUGLAS 2008-11-06 US disclosed
EP-1680404-A1 PROCESS FOR PRODUCING DIHYDROISOQUINOLINE ZWITTERIONS The Procter & Gamble Company (US) 2006-07-19 EP disclosed
US-20050113246-A1 Process of producing an organic catalyst THE PROCTER & GAMBLE COMPANY 2005-05-26 US disclosed
WO-2005047264-A1 PROCESS FOR PRODUCING DIHYDROISOQUINOLINE ZWITTERIONS THE PROCTER & GAMBLE COMPANY (US) 2005-05-26 WO disclosed