SCHEMBL8939338

SCHEMBL8939338

CCCCC(C#N)CCCc1ccc(-c2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.50
HSD17B10 Q99714 1/20 0.50
FDFT1 P37268 4/20 0.48
HSD11B1 P28845 2/20 0.48
MME P08473 1/20 0.47
ACE P12821 1/20 0.47
CPA1 P15085 1/20 0.47
ACE2 Q9BYF1 1/20 0.47
RARB P10826 4/20 0.44
BDKRB2 P30411 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8939339 0.95 TSHR (0.53) TSHRHSD17B10FDFT1HSD11B1MME
SCHEMBL8939324 0.94 TSHR (0.55) TSHRHSD17B10FDFT1HSD11B1MME
SCHEMBL8939328 0.94 TSHR (0.55) TSHRHSD17B10FDFT1HSD11B1MME
SCHEMBL8939308 0.94 TSHR (0.55) TSHRHSD17B10FDFT1HSD11B1MME
SCHEMBL8939310 0.94 FDFT1 (0.48) TSHRHSD17B10FDFT1HSD11B1MME
SCHEMBL3764837 0.89 FDFT1 (0.49) TSHRHSD17B10FDFT1HSD11B1MME
SCHEMBL5006472 0.83 CTSC (0.43)
SCHEMBL645917 0.81 FDFT1 (0.50) TSHRHSD17B10FDFT1HSD11B1
SCHEMBL28507541 0.80 HSD17B10 (0.65) TSHRHSD17B10HSD11B1RARB
SCHEMBL9158283 0.79 HSD11B1 (0.68) TSHRHSD17B10HSD11B1RARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-1085284-A None JP disclosed
US-5498363-A Electrorheological fluid AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 1996-03-12 US disclosed
US-5368770-A Method of preparing thin liquid crystal films KENT STATE UNIVERSITY (US) 1994-11-29 US disclosed
JP-S6485284-A LIQUID CRYSTAL COMPOSITION SANYO CHEMICAL IND LTD 1989-03-30 JP disclosed
US-4738908-A AQULENIUM SALT CANON KABUSHIKI KAISHA (JP) 1988-04-19 US disclosed
US-4390244-A Liquid crystal visual display unit and telephone terminal incorporating such a unit THOMSON-CSF (FR) 1983-06-28 US disclosed
US-4385807-A Visual display device with memory and telephone exchange incorporating such a device THOMSON-CSF (FR) 1983-05-31 US disclosed
EP-0023447-B1 LIQUID CRYSTAL DISPLAY DEVICE AND SUBSCRIBER SET COMPRISING SUCH A DEVICE THOMSON-CSF (FR) 1983-04-06 EP disclosed
EP-0063447-A1 Thermally addressed smectic liquid crystal device MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1982-10-27 EP disclosed
EP-0023447-A1 Liquid crystal display device and subscriber set comprising such a device THOMSON-CSF (FR) 1981-02-04 EP disclosed
US-4196974-A Smectic liquid crystal display cell THOMSON-CSF (FR) 1980-04-08 US disclosed