Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22339879 | 0.82 | SMYD3 (0.40) | ALDH1A1LMNAEPHX2NPC1RAB9A | |
| SCHEMBL1516954 | 0.80 | ALDH1A1 (0.50) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL8262999 | 0.80 | KDM4E (0.51) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL695370 | 0.79 | KDM4E (0.44) | ALDH1A1LMNAMAPTKDM4EALOX15 | |
| SCHEMBL24571244 | 0.77 | EPHX2 (0.40) | ALDH1A1LMNAEPHX2NPC1RAB9A | |
| SCHEMBL1564007 | 0.77 | NPC1 (0.45) | ALDH1A1LMNAEPHX2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL29903895 | 0.77 | KDM4E (0.43) | ALDH1A1LMNAMAPTKDM4EALOX15 | |
| SCHEMBL2422835 | 0.76 | IKBKB (0.39) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL19863561 | 0.76 | CCND1 (0.38) | ALDH1A1LMNAEPHX2NPC1RAB9A | |
| SCHEMBL24474544 | 0.76 | MAPT (0.47) | ALDH1A1LMNAMAPTKDM4ECNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | ASTEX THERAPEUTICS LIMITED (UK) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | GSK3A, CDK11A, CDK1 | ALDH1A1 1576/4885LMNA 367/4885EPHX2 3157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.