Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 2/20 | 0.48 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5006881 | 0.87 | MAPK1 (0.49) | MAPTMAPK1NPSR1MEN1KMT2A | |
| SCHEMBL4060770 | 0.80 | MAPT (0.46) | PDE1APDE1BPDE1CMAPTMAPK1 | |
| SCHEMBL5474702 | 0.72 | PDE4A (0.44) | PDE1CMAPTMAPK1NPSR1MEN1 | |
| SCHEMBL5103773 | 0.69 | PDE4A (0.60) | PDE1BMAPTMAPK1NPSR1MEN1 | |
| SCHEMBL17674931 | 0.69 | PDE1A (0.51) | PDE1APDE1BPDE1CALDH1A1PKM | |
| SCHEMBL17674859 | 0.68 | PDE1A (0.48) | PDE1APDE1BPDE1CMAPTMEN1 | |
| SCHEMBL17674924 | 0.68 | PDE1A (0.50) | PDE1APDE1BPDE1CMAPTMEN1 | |
| SCHEMBL4066139 | 0.67 | MAPT (0.43) | PDE1APDE1BPDE1CMAPTMEN1 | |
| SCHEMBL2348949 | 0.67 | PDE4A (0.85) | MAPTMEN1KMT2APDE4APDE4B | |
| SCHEMBL17674950 | 0.66 | PDE1A (0.46) | PDE1APDE1BPDE1CMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293744-A1 | Enantiomers of Selected Fused Pyrimidones and Uses in the Treatment and Prevention of Cancer | ASTRAZENECA AB (SE) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293744-A1 | Enantiomers of Selected Fused Pyrimidones and Uses in the Treatment and Prevention of Cancer | DHFR, DPYD, TYMS | PDE1A 1066/4885PDE1B 1029/4885PDE1C 1639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.