Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | PAICS | P22234 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30748858 | 0.88 | KDM4E (0.44) | ROCK1TDO2MEN1KMT2AKDM4E | |
| SCHEMBL2228866 | 0.84 | KDM4E (0.42) | MEN1KMT2AKDM4EPOLBRAB9A | |
| SCHEMBL30748953 | 0.84 | LOX (0.44) | MEN1KMT2AKDM4EPOLBRAB9A | |
| SCHEMBL1749039 | 0.84 | LOX (0.44) | MEN1KMT2AKDM4EPOLBRAB9A | |
| SCHEMBL30748869 | 0.83 | LOX (0.46) | MEN1KMT2AKDM4EPOLBRAB9A | |
| SCHEMBL12184685 | 0.83 | KDM4E (0.41) | ROCK1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL3651197 | 0.83 | LOX (0.46) | MEN1KMT2AKDM4EPOLBRAB9A | |
| SCHEMBL18423522 | 0.82 | TDO2 (0.47) | ROCK1TDO2HRH1IKBKBPAICS | |
| SCHEMBL19023755 | 0.81 | HRH1 (0.49) | ROCK1TDO2HRH1PRKCZIKBKB | |
| SCHEMBL3396466 | 0.80 | PIK3CA (0.41) | MEN1KMT2AKDM4EALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117658986-A | Preparation method of AR antagonist TRC-253 | 湖南师范大学 | 2024-03-08 | — | — | CN | claimed |
| CN-117658986-A | Preparation method of AR antagonist TRC-253 | 湖南师范大学 | 2024-03-08 | — | — | CN | disclosed |
| CN-117658986-A | Preparation method of AR antagonist TRC-253 | 湖南师范大学 | 2024-03-08 | — | — | CN | disclosed |
| WO-2011142359-A1 | SPIRO COMPOUND AND DRUG FOR ACTIVATING ADIPONECTIN RECEPTOR | 日産化学工業株式会社 (JP) | 2011-11-17 | — | — | WO | disclosed |
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | ASTEX THERAPEUTICS LIMITED (UK) | 2008-12-11 | — | — | US | disclosed |
| EP-1846395-A1 | PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDK'S AND GSK'S | Astex Therapeutics Limited (GB) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006077414-A1 | PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDK' S AND GSK' S | ASTEX THERAPEUTICS LIMITED (GB) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | GSK3A, CDK11A, CDK1 | ROCK1 574/4885TDO2 690/4885HRH1 3766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.