Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 13/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.44 |
| ▸ | PDE4A | P27815 | 4/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12545596 | 0.83 | PDK2 (0.52) | PGRPDK2PDK4PDE3BPDE3A | |
| SCHEMBL520415 | 0.73 | PDK2 (0.55) | PGRPDK2PDK4PDE3BPDE3A | |
| SCHEMBL7432516 | 0.73 | PGR (0.49) | PGRPDK2PDK4PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL31507926 | 0.71 | PDK2 (0.53) | PGRPDK2PDK4PDE3BPDE3A | |
| SCHEMBL31238639 | 0.71 | CYP1A2 (0.57) | PGRPDK2PDK4PDE3BPDE3A | |
| SCHEMBL2265773 | 0.71 | CYP1A2 (0.57) | PGRPDK2PDK4PDE3BPDE3A | |
| SCHEMBL15457685 | 0.70 | PDK2 (0.52) | PGRPDK2PDK4PDE3BPDE3A | |
| SCHEMBL10828050 | 0.70 | MAOB (0.51) | PGRPDK2PDK4PDE3BPDE3A | |
| SCHEMBL5008425 | 0.70 | MAOB (0.45) | PGRPDK2PDK4PDE3BPDE3A | |
| SCHEMBL12072640 | 0.69 | PDK2 (0.55) | PGRPDK2PDK4PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968950-A1 | PYRIMIDINE KINASE INHIBITORS | Genentech, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007120339-A1 | PYRIMIDINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2007-10-25 | — | — | WO | disclosed |