⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8354161 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL3848539 | 0.98 | — | — | |
| SCHEMBL19815561 | 0.77 | — | — | |
| SCHEMBL19815966 | 0.77 | — | — | |
| SCHEMBL7141789 | 0.76 | — | — | |
| SCHEMBL17180449 | 0.73 | CYP2D6 (0.37) | — | |
| SCHEMBL9733206 | 0.67 | CTSC (0.32) | — | |
| SCHEMBL19817500 | 0.64 | — | — | |
| Hydrochloric Acid SCHEMBL19815662 | 0.62 | — | — | |
| SCHEMBL23935463 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4055014-B1 | PYRROLIDINE AND PIPERIDINE COMPOUNDS | YUHAN CORP (KR) | 2025-04-30 | — | — | EP | claimed |
| CN-118165073-A | FAP inhibitor and preparation method and application thereof | 中国药科大学 | 2024-06-11 | — | — | CN | claimed |
| US-20250375540-A1 | FIBROBLAST ACTIVATION PROTEIN TARGETING PRECURSOR AND RADIOTRACER | ITM Oncologics GmbH (DE) | 2025-12-11 | — | — | US | disclosed |
| US-20250339566-A1 | INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN | UNIV ANTWERPEN (BE) | 2025-11-06 | — | — | US | disclosed |
| WO-2025106939-A1 | CONJUGATES TARGETING FIBROBLAST ACTIVATION PROTEIN AND USES THEREOF | Praxis Biotech LLC (US) | 2025-05-22 | — | — | WO | disclosed |
| EP-4547655-A1 | FIBROBLAST ACTIVATION PROTEIN TARGETING PRECURSOR AND RADIOTRACER | ITM Oncologics GmbH (DE) | 2025-05-07 | — | — | EP | disclosed |
| EP-4531932-A1 | INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN | Universiteit Antwerpen (BE) | 2025-04-09 | — | — | EP | disclosed |
| CN-119604492-A | Radiolabeled FAPI complex and preparation method and application thereof | 北京师范大学 | 2025-03-11 | — | — | CN | disclosed |
| CN-119546589-A | Precursor of targeted fibroblast activation protein and radiotracer | ITM肿瘤股份有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-114867719-B | Pyrrolidine and piperidine compounds | 柳韩洋行 | 2024-06-25 | — | — | CN | disclosed |
| WO-2024002853-A1 | FIBROBLAST ACTIVATION PROTEIN TARGETING PRECURSOR AND RADIOTRACER | Positron Precision GmbH (DE) | 2024-01-04 | — | — | WO | disclosed |
| WO-2023233023-A1 | INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN | UNIVERSITEIT ANTWERPEN (BE) | 2023-12-07 | — | — | WO | disclosed |
| US-11655235-B2 | Pyrrolidine and piperidine compounds | YUHAN CORPORATION (KR) | 2023-05-23 | — | — | US | disclosed |
| US-11655235-B2 | Pyrrolidine and piperidine compounds | YUHAN CORPORATION (KR) | 2023-05-23 | — | — | US | disclosed |
| CN-114867719-A | Pyrrolidine and piperidine compounds | 柳韩洋行 | 2022-08-05 | — | — | CN | disclosed |
| EP-4031184-A1 | FIBROBLAST ACTIVATION PROTEIN (FAP)-TARGETED IMAGING AND THERAPY OF CANCERS AND OTHER FIBROTIC AND INFLAMMATORY DISEASES | Purdue Research Foundation (US) | 2022-07-27 | — | — | EP | disclosed |
| US-20210147386-A1 | PYRROLIDINE AND PIPERIDINE COMPOUNDS | YUHAN CORPORATION (KR) | 2021-05-20 | — | — | US | disclosed |
| EP-1919864-A2 | FAP INHIBITORS | Ferring B.V. (NL) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007085895-A2 | FAP INHIBITORS | FERRING B.V. (US) | 2007-08-02 | — | — | WO | disclosed |
| WO-2004099185-A1 | 2-CYANOPYRROLIDINE DERIVATIVES AND THEIR USE AS DPP-IV INHIBITORS | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2004-11-18 | — | — | WO | disclosed |