SCHEMBL5010108

SCHEMBL5010108

CC1c2ccc(N(C)C)cc2Oc2cc(N(C)C)ccc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 5/20 0.41
TSHR P16473 5/20 0.41
LMNA P02545 4/20 0.41
MAPT P10636 4/20 0.41
ALOX15 P16050 4/20 0.41
MAPK1 P28482 4/20 0.41
TP53 P04637 3/20 0.41
GAA P10253 3/20 0.41
MEN1 O00255 2/20 0.41
HTT P42858 2/20 0.41
KMT2A Q03164 2/20 0.41
USP2 O75604 1/20 0.41
CASP1 P29466 1/20 0.41
CASP7 P55210 1/20 0.41
TDP1 Q9NUW8 4/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
NPC1 O15118 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ALDH1A1 P00352 7/20 0.39
HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16547109 0.86 TSHR (0.42) NPSR1TSHRLMNAMAPTALOX15
SCHEMBL10945528 0.85 MAPT (0.39) NPSR1TSHRLMNAMAPTALOX15
SCHEMBL3896114 0.79 MEN1 (0.43) NPSR1TSHRMAPTALOX15MAPK1
SCHEMBL3895025 0.79 NPSR1 (0.40) NPSR1TSHRLMNAMAPTALOX15
SCHEMBL8778242 0.79 ALOX15 (0.47) NPSR1TSHRLMNAMAPTALOX15
SCHEMBL9626207 0.77 NPSR1 (0.51) NPSR1TSHRLMNAMAPTALOX15
SCHEMBL20460704 0.75 MAPT (0.40) NPSR1TSHRLMNAMAPTALOX15
SCHEMBL16755698 0.75 MAPT (0.41) NPSR1TSHRLMNAMAPTALOX15
SCHEMBL18213661 0.75 MAPT (0.47) NPSR1TSHRLMNAMAPTALOX15
SCHEMBL14192856 0.75 NPSR1 (0.47) NPSR1TSHRLMNAMAPTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080311524-A1 Method For Making Negative-Working Heat-Sensitive Lithographic Printing Plate Precursor AGFA GRAPHICS N.V. (BE) 2008-12-18 US disclosed
US-7256291-B2 Labeling reagents comprising aphenylic analogs of rhodamine dyes ENZO LIFE SCIENCES, INC. (US) 2007-08-14 US disclosed
EP-1614541-A2 Method of making a lithographic printing plate. Agfa-Gevaert (BE) 2006-01-11 EP disclosed
EP-0239868-B1 PHOTOCHROMIC SYSTEM, LAYER PREPARED THEREOF AND ITS USE BASF Aktiengesellschaft (DE) 1989-12-27 EP disclosed
US-4857438-A Photochromic system and layers produced therewith BASF AKTIENGESELLSCHAFT (DE) 1989-08-15 US disclosed
EP-0239868-A1 Photochromic system, layer prepared thereof and its use BASF Aktiengesellschaft (DE) 1987-10-07 EP disclosed
US-4332884-A USING A DIOXIME CHELATING AGENT RICOH CO., LTD. (JP) 1982-06-01 US disclosed
US-4315068-A CONTAINING A COBALT-AMMINE COMPLEX AND A DIOXIME OR A BISIMIDAZOLIN-3-ONE CHELATING AGENT; STABILITY; COLOR DILMS RICOH CO., LTD. (JP) 1982-02-09 US disclosed
US-4306014-A AMMONIA OR AMINES SUPPRESS THE COLOR-FORMING REACTION SYSTEM RICOH CO., LTD. (JP) 1981-12-15 US disclosed
US-4251619-A Process for forming photo-polymeric image KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1981-02-17 US disclosed
US-4139390-A Presensitized printing plate having a print-out image EASTMAN KODAK COMPANY (US) 1979-02-13 US disclosed