Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ACACB | O00763 | 2/20 | 0.41 |
| ▸ | ACACA | Q13085 | 2/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460572 | 0.88 | FFAR1 (0.53) | NPC1RAB9AHSP90AA1L3MBTL1ALDH1A1 | |
| SCHEMBL8364280 | 0.82 | EPHX1 (0.45) | ACACBCARM1PRMT6EPHX2PPARG | |
| SCHEMBL4995830 | 0.81 | ACACB (0.47) | NPC1RAB9AALDH1A1ACACBACACA | |
| SCHEMBL4992970 | 0.80 | PARP10 (0.51) | NPC1RAB9AALDH1A1CARM1PRMT6 | |
| SCHEMBL4994474 | 0.80 | MAPK14 (0.52) | NPC1RAB9AALDH1A1MAPTEPHX2 | |
| SCHEMBL4985848 | 0.79 | OPRM1 (0.51) | SMN1; SMN2 | |
| SCHEMBL5010339 | 0.78 | S1PR1 (0.44) | ALDH1A1GAA | |
| SCHEMBL7457448 | 0.77 | SRD5A2 (0.47) | NPC1RAB9AL3MBTL1ALDH1A1MEN1 | |
| SCHEMBL4989136 | 0.77 | CYP3A4 (0.48) | GAAEPHX2SMN1; SMN2 | |
| SCHEMBL4995481 | 0.77 | CYP2C9 (0.56) | NPC1RAB9AL3MBTL1ALDH1A1CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281211-B1 | TREATING A DISORDER RESPONSIVE TO THE BLOCKADE OF SODIUM CHANNELS | EURO-CELTIQUE S.A. (LU) | 2001-08-28 | — | — | US | claimed |
| US-20080318932-A1 | Sodium Channel Blocker Compositions and the Use Thereof | PURDUE PHARMA L.P. (US) | 2008-12-25 | — | — | US | disclosed |
| EP-1169060-B1 | SODIUM CHANNEL BLOCKER COMPOSITIONS AND THE USE THEREOF | EURO CELTIQUE SA (LU) | 2005-08-31 | — | — | EP | disclosed |
| US-20020037926-A1 | Sodium channel blocker compositions and the use thereof | PURDUE PHARMA LTD. | 2002-03-28 | — | — | US | disclosed |
| WO-2000061188-A9 | SODIUM CHANNEL BLOCKER COMPOSITIONS AND THE USE THEREOF | EURO CELTIQUE SA (LU) | 2002-02-14 | — | — | WO | disclosed |
| US-6281211-B1 | TREATING A DISORDER RESPONSIVE TO THE BLOCKADE OF SODIUM CHANNELS | EURO-CELTIQUE S.A. (LU) | 2001-08-28 | — | — | US | disclosed |
| WO-1999039712-A9 | SUBSTITUTED SEMICARBAZIDES AND THE USE THEREOF | COCENSYS INC (US) | 1999-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318932-A1 | Sodium Channel Blocker Compositions and the Use Thereof | CACNA1B, CACNB2, CACNA1C | NPC1 978/4885RAB9A 2550/4885HSP90AA1 2524/4885 |
| US-20020037926-A1 | Sodium channel blocker compositions and the use thereof | CACNA1B, CACNB2, CACNA1C | NPC1 978/4885RAB9A 2550/4885HSP90AA1 2524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.