Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.59 |
| ▸ | MLYCD | O95822 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 6/20 | 0.42 |
| ▸ | CA9 | Q16790 | 6/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.31 |
| ▸ | SORD | Q00796 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2979741 | 0.97 | MLYCD (0.58) | ALOX5MLYCDCA12CA9ALDH2 | |
| SCHEMBL2983368 | 0.93 | MLYCD (0.56) | ALOX5MLYCDCA12CA9ALDH2 | |
| SCHEMBL2991946 | 0.87 | MLYCD (0.71) | ALOX5MLYCDCA12CA9ALDH2 | |
| SCHEMBL2990446 | 0.85 | MLYCD (0.59) | ALOX5MLYCDCA12CA9ALDH2 | |
| SCHEMBL2987971 | 0.85 | MLYCD (0.65) | ALOX5MLYCDCA12CA9 | |
| SCHEMBL2979837 | 0.83 | MLYCD (0.57) | ALOX5MLYCDCA12CA9 | |
| SCHEMBL2984933 | 0.83 | MLYCD (0.57) | ALOX5MLYCDCA12CA9 | |
| SCHEMBL2985044 | 0.83 | MLYCD (0.57) | ALOX5MLYCDCA12CA9 | |
| SCHEMBL2982483 | 0.83 | MLYCD (0.57) | ALOX5MLYCDCA12CA9 | |
| SCHEMBL2987497 | 0.83 | MLYCD (0.57) | ALOX5MLYCDCA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439260-B2 | 7-(1,3-thiazol-2-YL)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors | MERCK FORSST CANADA & CO. (CA) | 2008-10-21 | — | — | US | disclosed |
| EP-1636222-A1 | 7-[(1,3-THIAZOL-2-YL)THIO]-COUMARIN DERIVATIVES AND THEIR USE AS LEUKOTRIENE BIOSYNTHESIS INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004108720-A1 | 7- (1, 3-THIAZOL-2-YL)THIO!-COUMARIN DERIVATIVES AND THEIR USE AS LEUKOTRIENE BIOSYNTHESIS INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2004-12-16 | — | — | WO | disclosed |