Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.59 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.59 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5010659 | 0.92 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL5005267 | 0.88 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL5010696 | 0.86 | ADORA1 (0.54) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL5007721 | 0.86 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11GFER | |
| SCHEMBL5007743 | 0.86 | CLCN2 (0.51) | MAPK14MAPK13MAPK12MAPK11GFER | |
| SCHEMBL5010626 | 0.84 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL5008471 | 0.84 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11ADORA1 | |
| SCHEMBL14600217 | 0.83 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11GFER | |
| SCHEMBL5008768 | 0.83 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11GFER | |
| SCHEMBL5005515 | 0.83 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064734-A1 | Anilinopyrazole derivatives useful for the treatment of diabetes | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-03-13 | — | — | US | disclosed |
| US-7265144-B2 | Anilinopyrazole derivatives useful for the treatment of diabetes | BAYER PHARMACEUTICALS CORPORATION (US) | 2007-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064734-A1 | Anilinopyrazole derivatives useful for the treatment of diabetes | IAPP, GLP1R, GPR119 | MAPK14 1938/4885MAPK13 885/4885MAPK12 1488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.