Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | AGPAT2 | O15120 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5010265 | 0.92 | ALDH1A1 (0.42) | MCL1TP53MAPTALDH1A1NPC1 | |
| SCHEMBL3557513 | 0.91 | MCL1 (0.48) | MCL1TP53MAPTTHRBCNR1 | |
| SCHEMBL3558055 | 0.87 | MCL1 (0.42) | MCL1TP53MAPTTHRBCNR1 | |
| SCHEMBL3553767 | 0.87 | BTK (0.43) | MCL1THRBALDH1A1 | |
| SCHEMBL5010251 | 0.87 | MCL1 (0.42) | MCL1TP53MAPTTHRBCNR1 | |
| SCHEMBL3560389 | 0.86 | MCL1 (0.52) | MCL1MAPTTHRBALDH1A1NPC1 | |
| SCHEMBL3553532 | 0.85 | MCL1 (0.43) | MCL1MAPTTHRB | |
| SCHEMBL5011218 | 0.84 | MCL1 (0.41) | MCL1TP53THRBALDH1A1TSHR | |
| SCHEMBL3554326 | 0.84 | KDM4E (0.47) | MCL1TP53MAPTCNR1ALDH1A1 | |
| SCHEMBL3102308 | 0.84 | MCL1 (0.50) | MCL1MAPTTHRBCNR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7420066-B2 | Benzofuran derivatives useful for treating hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-09-02 | — | — | US | disclosed |
| US-20060194816-A1 | Benzofuran derivatives useful for treating hyper-proliferative disorders | BAER PHAMACEUTICALS CORPORATION (US) | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194816-A1 | Benzofuran derivatives useful for treating hyper-proliferative disorders | MKI67, PCNA, CCNI | MCL1 55/4885AGPAT2 3867/4885TP53 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.