Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011739 | 0.85 | DHODH (0.49) | PTPN1NPSR1NAMPTKMT2AMEN1 | |
| SCHEMBL5014676 | 0.84 | PTPN1 (0.56) | PTPN1NPSR1NAMPTKMT2AMEN1 | |
| SCHEMBL5011271 | 0.82 | PTPN1 (0.51) | PTPN1NPSR1NAMPTKMT2AMEN1 | |
| SCHEMBL24645052 | 0.76 | NPSR1 (0.69) | PTPN1NPSR1NAMPTKMT2AMEN1 | |
| SCHEMBL7972835 | 0.74 | NPSR1 (0.71) | NPSR1NAMPTKMT2AMEN1LMNA | |
| SCHEMBL5011831 | 0.74 | PTPN1 (0.48) | PTPN1NPSR1NAMPTKMT2AMEN1 | |
| SCHEMBL21242857 | 0.73 | PTPN1 (0.67) | PTPN1NPSR1NAMPTKMT2AMEN1 | |
| SCHEMBL14734057 | 0.72 | KMT2A (0.78) | PTPN1NAMPTKMT2AMEN1LMNA | |
| SCHEMBL24645051 | 0.72 | NPSR1 (0.68) | PTPN1NPSR1NAMPTKMT2AMEN1 | |
| SCHEMBL17224981 | 0.72 | PTPN1 (0.65) | PTPN1NAMPTKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893562-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | Merck Frosst Canada Ltd. (CA) | 2008-03-05 | — | — | EP | claimed |
| WO-2006133559-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | MERCK FROSST CANADA LTD. (CA) | 2006-12-21 | — | — | WO | claimed |
| EP-1893562-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | Merck Frosst Canada Ltd. (CA) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133559-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | MERCK FROSST CANADA LTD. (CA) | 2006-12-21 | — | — | WO | disclosed |