Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.53 |
| ▸ | TSHR | P16473 | 6/20 | 0.53 |
| ▸ | USP2 | O75604 | 8/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 2/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5010920 | 1.00 | CYP3A4 (0.53) | CYP3A4TSHRUSP2HSD17B10CYP2C9 | |
| SCHEMBL7109251 | 0.90 | RHOC (0.49) | CYP3A4TSHRUSP2HSD17B10CYP2C9 | |
| SCHEMBL7109255 | 0.90 | RHOC (0.49) | CYP3A4TSHRUSP2HSD17B10CYP2C9 | |
| SCHEMBL5012629 | 0.90 | CYP3A4 (0.46) | CYP3A4TSHRUSP2HSD17B10CYP2C9 | |
| SCHEMBL5014232 | 0.90 | CYP3A4 (0.46) | CYP3A4TSHRUSP2HSD17B10CYP2C9 | |
| SCHEMBL5010895 | 0.87 | TSHR (0.46) | CYP3A4TSHRUSP2HSD17B10CYP2C9 | |
| SCHEMBL5012597 | 0.87 | TSHR (0.46) | CYP3A4TSHRUSP2HSD17B10CYP2C9 | |
| SCHEMBL4558250 | 0.87 | CRBN (0.46) | TSHRCYP2C9CYP2D6ALDH1A1HPGD | |
| SCHEMBL5010886 | 0.87 | RHOA (0.47) | CYP3A4TSHRUSP2HSD17B10CYP2C9 | |
| SCHEMBL5010884 | 0.87 | RHOA (0.47) | CYP3A4TSHRUSP2HSD17B10CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390372-B1 | 1-OXA-3,9-DIAZA-SPIRO'5,5]UNDECAN-2-ONES DERIVATIVES AND ITS USE AS ANTAGONIST OF THE NEURIKININ RECEPTOR | HOFFMANN LA ROCHE (CH) | 2008-07-16 | — | — | EP | claimed |
| US-6599900-B2 | Antiinflammatory agents; headaches; antiarthritic agents | SYNTEX (U.S.A.) LLC | 2003-07-29 | — | — | US | claimed |
| US-20030004163-A1 | 1-Oxa-3,9-diaza-spiro[5,5]undecan-2-ones | SYNTEX (U.S.A) LLC | 2003-01-02 | — | — | US | claimed |
| EP-1390372-B1 | 1-OXA-3,9-DIAZA-SPIRO'5,5]UNDECAN-2-ONES DERIVATIVES AND ITS USE AS ANTAGONIST OF THE NEURIKININ RECEPTOR | HOFFMANN LA ROCHE (CH) | 2008-07-16 | — | — | EP | disclosed |
| US-6599900-B2 | Antiinflammatory agents; headaches; antiarthritic agents | SYNTEX (U.S.A.) LLC | 2003-07-29 | — | — | US | disclosed |
| US-20030004163-A1 | 1-Oxa-3,9-diaza-spiro[5,5]undecan-2-ones | SYNTEX (U.S.A) LLC | 2003-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004163-A1 | 1-Oxa-3,9-diaza-spiro[5,5]undecan-2-ones | OXER1, NR4A1, OXGR1 | CYP3A4 1472/4885TSHR 298/4885USP2 4097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.