Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 5/20 | 0.58 |
| ▸ | CA9 | Q16790 | 4/20 | 0.58 |
| ▸ | CA2 | P00918 | 4/20 | 0.58 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL129104 | 0.81 | ERN1 (0.59) | ERN1CA1CA9CA2MAPT | |
| Ammonia Solution, Strong SCHEMBL8762521 | 0.80 | ERN1 (0.58) | ERN1CA1CA9CA2MAPT | |
| SCHEMBL3726105 | 0.80 | ERN1 (0.58) | ERN1CA1CA9CA2MAPT | |
| SCHEMBL1192730 | 0.80 | ERN1 (0.53) | ERN1CA1CA9CA2MAPT | |
| Potassium Ion SCHEMBL8630608 | 0.80 | ERN1 (0.53) | ERN1CA1CA9CA2MAPT | |
| Formaldehyde SCHEMBL10629971 | 0.79 | ERN1 (0.56) | ERN1CA1CA9CA2MAPT | |
| SCHEMBL29786464 | 0.79 | CA1 (0.64) | ERN1CA1CA9CA2LDHA | |
| Sulfamide SCHEMBL12076368 | 0.78 | ERN1 (0.59) | ERN1CA1CA9CA2MAPT | |
| SCHEMBL16568785 | 0.77 | ERN1 (0.50) | ERN1CA1CA9CA2MAPT | |
| SCHEMBL2313681 | 0.77 | MAPT (0.50) | ERN1CA1CA9CA2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904474-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007008140-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |