Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 19/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | GLA | P06280 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | STAT6 | P42226 | 1/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.60 |
| ▸ | GMNN | O75496 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | HNRNPA1 | P09651 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1385182 | 0.95 | TOP1 (0.83) | TOP1ALDH1A1GLAKDM4ETP53 | |
| SCHEMBL1381473 | 0.93 | TOP1 (0.81) | TOP1ALDH1A1GLAKDM4ETP53 | |
| SCHEMBL28759768 | 0.93 | TOP1 (0.78) | TOP1ALDH1A1GLAKDM4ETP53 | |
| SCHEMBL5014520 | 0.93 | TOP1 (0.78) | TOP1ALDH1A1GLAKDM4ETP53 | |
| SCHEMBL5011258 | 0.92 | TOP1 (0.76) | TOP1ALDH1A1GLAKDM4ETP53 | |
| SCHEMBL5011496 | 0.91 | TOP1 (0.75) | TOP1ALDH1A1GLAKDM4ETP53 | |
| SCHEMBL1386720 | 0.90 | TOP1 (0.73) | TOP1ALDH1A1GLAKDM4ETP53 | |
| SCHEMBL1382878 | 0.90 | TOP1 (0.85) | TOP1ALDH1A1GLAKDM4ETP53 | |
| SCHEMBL5012704 | 0.89 | TOP1 (0.72) | TOP1ALDH1A1GLAKDM4ETP53 | |
| SCHEMBL26514712 | 0.88 | TOP1 (0.80) | TOP1ALDH1A1GLAKDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006520807-A | — | — | 2006-09-14 | — | — | JP | claimed |
| US-7105492-B2 | Camptothecin derivatives having antitumor activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-09-12 | — | — | US | claimed |
| US-20060167033-A1 | 7-Imino derivatives of camptothecin having antitumor activity | ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI (IT) | 2006-07-27 | — | — | US | claimed |
| EP-1603919-A1 | 7-IMINO DERIVATIVES OF CAMPTOTHECIN HAVING ANTITUMOR ACTIVITY | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2005-12-14 | — | — | EP | claimed |
| WO-2004083214-A1 | 7-IMINO DERIVATIVES OF CAMPTOTHECIN HAVING ANTITUMOR ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-09-30 | — | — | WO | claimed |
| US-20040018988-A1 | Camptothecin derivatives having antitumor activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-01-29 | — | — | US | claimed |
| US-7351714-B2 | 7-imino derivatives of camptothecin having antitumor activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-04-01 | — | — | US | disclosed |
| US-7105492-B2 | Camptothecin derivatives having antitumor activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-09-12 | — | — | US | disclosed |
| US-20060167033-A1 | 7-Imino derivatives of camptothecin having antitumor activity | ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI (IT) | 2006-07-27 | — | — | US | disclosed |
| EP-1603919-A1 | 7-IMINO DERIVATIVES OF CAMPTOTHECIN HAVING ANTITUMOR ACTIVITY | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004083214-A1 | 7-IMINO DERIVATIVES OF CAMPTOTHECIN HAVING ANTITUMOR ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-09-30 | — | — | WO | disclosed |
| US-20040018988-A1 | Camptothecin derivatives having antitumor activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167033-A1 | 7-Imino derivatives of camptothecin having antitumor activity | TYMP, TOP1, TOP2A | TOP1 2/4885ALDH1A1 2013/4885GLA 2726/4885 |
| US-20040018988-A1 | Camptothecin derivatives having antitumor activity | TOP1, TOP2A, TOP2B | TOP1 1/4885ALDH1A1 1248/4885GLA 1972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.