Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.80 |
| ▸ | HTT | P42858 | 4/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.80 |
| ▸ | THRB | P10828 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.79 |
| ▸ | HPGD | P15428 | 8/20 | 0.78 |
| ▸ | MAPT | P10636 | 5/20 | 0.78 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.78 |
| ▸ | PKM | P14618 | 1/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.73 |
| ▸ | POLB | P06746 | 5/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.56 |
| ▸ | PDE4A | P27815 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014746 | 0.89 | KDM4E (0.75) | KDM4EALDH1A1HTTHIF1ATHRB | |
| SCHEMBL5012337 | 0.88 | KDM4E (1.00) | KDM4EALDH1A1HTTHIF1ATHRB | |
| SCHEMBL5015871 | 0.88 | KDM4E (0.73) | KDM4EALDH1A1HTTHIF1ATHRB | |
| SCHEMBL5012457 | 0.86 | KDM4E (0.79) | KDM4EALDH1A1HTTHIF1ATHRB | |
| SCHEMBL5012464 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1ADRB2HPGDMAPT | |
| SCHEMBL5013135 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1HTTHIF1ATHRB | |
| SCHEMBL5013116 | 0.83 | PDE4B (0.76) | KDM4EALDH1A1HTTHIF1ATHRB | |
| SCHEMBL4176858 | 0.78 | ALDH1A1 (0.67) | KDM4EALDH1A1HTTHIF1ATHRB | |
| SCHEMBL4047007 | 0.77 | PDE4B (0.70) | KDM4EALDH1A1HTTHIF1ATHRB | |
| SCHEMBL5135624 | 0.76 | KDM4E (0.83) | KDM4EALDH1A1HTTHIF1ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207645-A1 | Pyridothienopyrimidine Derivatives | PAGES SANTACANA LUIS MIGUEL | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207645-A1 | Pyridothienopyrimidine Derivatives | PDE4A, PDE5A, PDE3B | KDM4E 1526/4885ALDH1A1 438/4885HTT 4161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.