Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503863 | 1.00 | SYK (0.39) | SYKCTSKCTSLCTSBCTSF | |
| SCHEMBL4492399 | 0.81 | SYK (0.39) | SYKCTSKCTSLCTSBCTSF | |
| SCHEMBL4503752 | 0.81 | SYK (0.39) | SYKCTSKCTSLCTSBCTSF | |
| SCHEMBL7803590 | 0.81 | PTPN5 (0.39) | SYKCTSKCTSLCTSBCTSF | |
| SCHEMBL14593355 | 0.80 | ESR1 (0.48) | ESR1ESR2 | |
| SCHEMBL8988146 | 0.79 | ESR1 (0.58) | ESR1ESR2 | |
| SCHEMBL12628146 | 0.79 | KIF11 (0.46) | PTPN5 | |
| SCHEMBL4497165 | 0.79 | KIF11 (0.46) | PTPN5 | |
| SCHEMBL4515042 | 0.78 | PTPN5 (0.51) | CTSKESR1ESR2PTPN5 | |
| SCHEMBL28275254 | 0.77 | CYP3A4 (0.49) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893562-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | Merck Frosst Canada Ltd. (CA) | 2008-03-05 | — | — | EP | claimed |
| WO-2006133559-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | MERCK FROSST CANADA LTD. (CA) | 2006-12-21 | — | — | WO | claimed |
| EP-1893562-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | Merck Frosst Canada Ltd. (CA) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133559-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | MERCK FROSST CANADA LTD. (CA) | 2006-12-21 | — | — | WO | disclosed |