Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | STAT3 | P40763 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27956765 | 0.87 | KDM4E (0.60) | KDM4ESTAT3HIF1ASMN1; SMN2LMNA | |
| SCHEMBL27956770 | 0.86 | KDM4E (0.58) | KDM4ESTAT3HIF1ASMN1; SMN2LMNA | |
| SCHEMBL4603741 | 0.82 | PRKAG1 (0.51) | — | |
| SCHEMBL30258217 | 0.81 | KDM4E (0.63) | KDM4ESTAT3HIF1ASMN1; SMN2MAP2K4 | |
| SCHEMBL498163 | 0.81 | KDM4E (0.63) | KDM4ESTAT3HIF1ASMN1; SMN2MAP2K4 | |
| SCHEMBL12788089 | 0.80 | KDM4E (0.65) | KDM4ESTAT3HIF1ASMN1; SMN2RAB9A | |
| SCHEMBL16516393 | 0.78 | KDM4E (0.63) | KDM4ESTAT3HIF1ASMN1; SMN2LMNA | |
| SCHEMBL14574212 | 0.78 | KDM4E (0.63) | KDM4ESTAT3HIF1ASMN1; SMN2RAB9A | |
| SCHEMBL15882110 | 0.78 | MAP2K4 (0.65) | KDM4ESTAT3HIF1ASMN1; SMN2LMNA | |
| SCHEMBL31725376 | 0.78 | MAP2K4 (0.65) | KDM4ESTAT3HIF1ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984360-A2 | COMPOUNDS AND METHODS FOR MODULATING FX-RECEPTORS | Eli Lilly & Company (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007092751-A2 | COMPOUNDS AND METHODS FOR MODULATING FX-RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-16 | — | — | WO | disclosed |