Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.64 |
| ▸ | GSK3B | P49841 | 6/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.61 |
| ▸ | CLK2 | P49760 | 2/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.61 |
| ▸ | CLK3 | P49761 | 1/20 | 0.61 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.61 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.61 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.56 |
| ▸ | PIM1 | P11309 | 5/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15640023 | 0.84 | TGFBR1 (0.70) | CLK1GSK3BDYRK3CLK2CDK5 | |
| SCHEMBL38663679 | 0.80 | CLK1 (0.57) | CLK1GSK3BDYRK3CLK2CDK5 | |
| SCHEMBL3799521 | 0.80 | CLK1 (0.61) | CLK1GSK3BDYRK3CLK2CDK5 | |
| SCHEMBL2029580 | 0.78 | CLK1 (0.55) | CLK1GSK3BDYRK3CLK2CDK5 | |
| SCHEMBL4791316 | 0.78 | CLK1 (1.00) | CLK1GSK3BDYRK3CLK2CDK5 | |
| SCHEMBL7572389 | 0.77 | TGFBR1 (0.50) | CLK1GSK3BDYRK3CLK2CDK5 | |
| SCHEMBL30627398 | 0.77 | TGFBR1 (0.50) | CLK1GSK3BDYRK3CLK2CDK5 | |
| SCHEMBL15639988 | 0.76 | TGFBR1 (0.70) | CLK1GSK3BDYRK3CLK2CDK5 | |
| SCHEMBL30805622 | 0.76 | GSK3B (0.63) | CLK1GSK3BDYRK3CLK2CDK5 | |
| SCHEMBL20658446 | 0.76 | GSK3B (0.61) | CLK1GSK3BDYRK3CLK2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962853-A1 | (INDAZOL-5-YL)-PYRAZINES AND (1,3-DIHYDRO-INDOL-2-ONE)- PYRAZINES FOR TREATING RHO KINASE-MEDIATED DISEASES AND CONDITIONS | Alcon Research, Ltd. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007076360-A8 | (INDAZOL-5-YL)-PYRAZINES AND (1,3-DIHYDRO-INDOL-2-ONE)- PYRAZINES FOR TREATING RHO KINASE-MEDIATED DISEASES AND CONDITIONS | ALCON MFG LTD (US) | 2007-12-06 | — | — | WO | disclosed |
| WO-2007076360-A1 | (INDAZOL-5-YL)-PYRAZINES AND (1,3-DIHYDRO-INDOL-2-ONE)- PYRAZINES FOR TREATING RHO KINASE-MEDIATED DISEASES AND CONDITIONS | ALCON RESEARCH, LTD. (US) | 2007-07-05 | — | — | WO | disclosed |