Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 6/20 | 0.37 |
| ▸ | BCHE | P06276 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012237 | 0.94 | KMT2A (0.43) | KMT2AACHEBCHE | |
| SCHEMBL16175774 | 0.92 | CYP3A4 (0.41) | KMT2A | |
| SCHEMBL5014557 | 0.91 | CHRM3 (0.40) | KMT2AACHEBCHEMAPT | |
| SCHEMBL16175752 | 0.90 | KMT2A (0.42) | KMT2A | |
| SCHEMBL5012967 | 0.90 | KMT2A (0.42) | KMT2AMAPT | |
| SCHEMBL5012923 | 0.90 | KMT2A (0.46) | KMT2A | |
| SCHEMBL5012976 | 0.90 | KMT2A (0.41) | KMT2AACHEBCHEMAPT | |
| SCHEMBL5065032 | 0.90 | KMT2A (0.43) | KMT2AACHEBCHE | |
| SCHEMBL5012814 | 0.90 | KMT2A (0.42) | KMT2AMAPT | |
| SCHEMBL5012856 | 0.90 | KMT2A (0.42) | KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |