Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 4/20 | 0.35 |
| ▸ | BCHE | P06276 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014557 | 0.92 | CHRM3 (0.40) | KMT2AMAPTCHRM3ACHEBCHE | |
| SCHEMBL5012843 | 0.90 | CHRM3 (0.39) | KMT2AMEN1CHRM3TRPV1 | |
| SCHEMBL5012846 | 0.90 | CHRM3 (0.39) | KMT2ARAB9ACHRM3TRPV1EPHX2 | |
| SCHEMBL5014388 | 0.90 | KMT2A (0.43) | KMT2AMAPTACHEBCHE | |
| SCHEMBL5012237 | 0.90 | KMT2A (0.43) | KMT2ARAB9AACHEBCHE | |
| SCHEMBL5012853 | 0.90 | CCR3 (0.41) | KMT2AMAPTCHRM3ABCG2 | |
| SCHEMBL5014467 | 0.90 | CHRM3 (0.41) | KMT2AHTTCHRM3TRPV1ACHE | |
| SCHEMBL5015823 | 0.90 | CHRM3 (0.39) | KMT2ACHRM3TRPV1EPHX2ABCG2 | |
| SCHEMBL5012231 | 0.89 | TRPM8 (0.39) | KMT2ACHRM3TRPV1 | |
| SCHEMBL16175697 | 0.89 | TRPM8 (0.39) | KMT2AMEN1RAB9ACHRM3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |