⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4882 | 0.78 | — | — | |
| SCHEMBL8893626 | 0.72 | — | — | |
| SCHEMBL6970847 | 0.72 | — | — | |
| SCHEMBL6972746 | 0.72 | — | — | |
| SCHEMBL863004 | 0.70 | — | — | |
| SCHEMBL29540011 | 0.70 | — | — | |
| SCHEMBL5692364 | 0.70 | — | — | |
| SCHEMBL8893329 | 0.69 | — | — | |
| SCHEMBL426487 | 0.67 | — | — | |
| SCHEMBL6243868 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1992349-B1 | CGRP antagonists, their preparation and use as a medicament | BOEHRINGER INGELHEIM INT (DE) | 2013-07-31 | — | — | EP | claimed |
| EP-1992349-A1 | CGRP antagonists, their preparation and use as a medicament | Boehringer Ingelheim International GmbH (DE) | 2008-11-19 | — | — | EP | claimed |
| EP-1863791-A1 | 2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-YL-PIPERIDINES USED AS CGRP ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2007-12-12 | — | — | EP | claimed |
| WO-2006100026-A1 | 2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-YL-PIPERIDINES USED AS CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-09-28 | — | — | WO | claimed |
| EP-1054669-B9 | USE OF THIADIAZOLO[4,3-A]PYRIDINE DERIVATIVES | ROCHE DIAGNOSTICS GMBH (DE) | 2004-09-15 | — | — | EP | claimed |
| EP-1054669-B1 | USE OF THIADIAZOLO[4,3-A]PYRIDINE DERIVATIVES | ROCHE DIAGNOSTICS GMBH (DE) | 2003-07-16 | — | — | EP | claimed |
| EP-0772597-B1 | 3,4-SUBSTITUTED PYRAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2001-12-12 | — | — | EP | claimed |
| US-6326378-B1 | LEUKEMIA THERAPY | ROCHE DIAGNOSTICS GMBH (DE) | 2001-12-04 | — | — | US | claimed |
| EP-1127878-A1 | 3,4 - substituted pyrazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-29 | — | — | EP | claimed |
| US-6028072-A | 3,4-substituted pyrazoles for the treatment of inflammation | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | claimed |
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | claimed |
| US-5486534-A | 3,4-substituted pyrazoles for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-01-23 | — | — | US | claimed |
| US-5447934-A | Anti-allergic thiadiazolo [4,3-a]pyridine derivatives | BOEHRINGER MANNHEIM GMBH (DE) | 1995-09-05 | — | — | US | claimed |
| EP-1992349-B1 | CGRP antagonists, their preparation and use as a medicament | BOEHRINGER INGELHEIM INT (DE) | 2013-07-31 | — | — | EP | disclosed |
| EP-1992349-A1 | CGRP antagonists, their preparation and use as a medicament | Boehringer Ingelheim International GmbH (DE) | 2008-11-19 | — | — | EP | disclosed |
| EP-1992349-A1 | CGRP antagonists, their preparation and use as a medicament | Boehringer Ingelheim International GmbH (DE) | 2008-11-19 | — | — | EP | disclosed |
| EP-0605493-A1 | THIADIAZOLO 4,3-a]PYRIDINE DERIVATIVES, METHODS OF PREPARING THEM AND DRUGS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1994-07-13 | — | — | EP | disclosed |
| WO-1993006109-A1 | THIADIAZOLO[4,3-a]PYRIDINE DERIVATIVES, METHODS OF PREPARING THEM AND DRUGS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1993-04-01 | — | — | WO | disclosed |
| EP-0222322-B1 | CEPHALOSPORIN DERIVATIVES AND PROCESS FOR THEIR PREPARATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-05-06 | — | — | EP | disclosed |
| EP-0222322-A2 | Cephalosporin derivatives and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-05-20 | — | — | EP | disclosed |