Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 12/20 | 0.52 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011615 | 0.87 | ABL1 (0.52) | ABL1MAPTNPC1RAB9AGSK3B | |
| SCHEMBL5011739 | 0.74 | DHODH (0.49) | ABL1DHODHPARP1MAPTNPC1 | |
| SCHEMBL5011321 | 0.73 | ABL1 (0.48) | ABL1DHODHPARP1MAPTNPC1 | |
| SCHEMBL5009744 | 0.71 | DHODH (0.50) | ABL1DHODHPARP1MAPTNPC1 | |
| SCHEMBL4500620 | 0.71 | APP (0.48) | — | |
| SCHEMBL17236518 | 0.71 | DHODH (0.52) | ABL1DHODHPARP1MAPTNPC1 | |
| SCHEMBL14244797 | 0.68 | ABL1 (1.00) | ABL1 | |
| SCHEMBL14244796 | 0.68 | ABL1 (1.00) | ABL1 | |
| SCHEMBL14245297 | 0.68 | ABL1 (1.00) | ABL1 | |
| SCHEMBL26633318 | 0.67 | JAK2 (0.40) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893562-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | Merck Frosst Canada Ltd. (CA) | 2008-03-05 | — | — | EP | claimed |
| WO-2006133559-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | MERCK FROSST CANADA LTD. (CA) | 2006-12-21 | — | — | WO | claimed |
| EP-1893562-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | Merck Frosst Canada Ltd. (CA) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133559-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | MERCK FROSST CANADA LTD. (CA) | 2006-12-21 | — | — | WO | disclosed |