Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2453458 | 0.74 | PNMT (0.46) | PNMTAKR1C1DGAT1SOAT1MEN1 | |
| SCHEMBL5012327 | 0.72 | KDM4E (0.33) | — | |
| SCHEMBL2452042 | 0.71 | PNMT (0.59) | PNMTAKR1C1LMNADGAT1SOAT1 | |
| SCHEMBL12302201 | 0.68 | PNMT (0.55) | PNMTAKR1C1LMNADGAT1SOAT1 | |
| SCHEMBL2453099 | 0.68 | PNMT (0.55) | PNMTAKR1C1LMNADGAT1SOAT1 | |
| SCHEMBL2447393 | 0.67 | PNMT (0.54) | PNMTAKR1C1MEN1CYP2C9KMT2A | |
| SCHEMBL2452508 | 0.66 | PNMT (0.52) | PNMTAKR1C1LMNADGAT1SOAT1 | |
| SCHEMBL15897778 | 0.65 | PNMT (0.55) | PNMTAKR1C1MEN1CYP2C9KMT2A | |
| SCHEMBL20743587 | 0.65 | PNMT (0.50) | PNMTAKR1C1LMNADGAT1SOAT1 | |
| SCHEMBL1502311 | 0.65 | MEN1 (0.51) | PNMTAKR1C1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966221-A1 | PYRIMIDO- [4, 5-]-OXAZINES FOR USE AS DGAT INHIBITORS | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071966-A1 | PYRIMIDO- [4, 5-B] -OXAZINES FOR USE AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |