Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3113301 | 0.90 | CYP1A2 (0.44) | CYP1A2CYP2C19CYP2C9MTNR1ANQO2 | |
| SCHEMBL2092694 | 0.89 | SIGMAR1 (0.42) | GPR84CYP1A2CYP2C19CYP2C9SIGMAR1 | |
| SCHEMBL108121 | 0.82 | CYP1A2 (0.50) | GPR84CYP1A2CYP2C19MCL1CYP2C9 | |
| SCHEMBL27873879 | 0.82 | CNR2 (0.45) | GPR84CYP1A2CYP2C19MCL1CYP2C9 | |
| SCHEMBL12251120 | 0.81 | BCHE (0.45) | GPR84CYP1A2CYP2C19CYP2C9SIGMAR1 | |
| SCHEMBL2094192 | 0.81 | NQO2 (0.46) | GPR84CYP1A2CYP2C19MCL1CYP2C9 | |
| SCHEMBL6420346 | 0.81 | CYP1A2 (0.46) | CYP1A2CYP2C19CYP2C9CYP2D6 | |
| SCHEMBL134471 | 0.80 | CYP1A2 (0.48) | GPR84CYP1A2CYP2C19MCL1CYP2C9 | |
| SCHEMBL586305 | 0.80 | CYP1A2 (0.52) | CYP1A2CYP2C19CYP2C9SLC18A2MTNR1A | |
| Hydrochloric Acid SCHEMBL9517776 | 0.80 | BCHE (0.47) | CYP1A2CYP2C19CYP2C9SIGMAR1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |
| CN-1878777-A | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2006-12-13 | — | — | CN | disclosed |