Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.59 |
| ▸ | CA2 | P00918 | 6/20 | 0.59 |
| ▸ | CA12 | O43570 | 5/20 | 0.59 |
| ▸ | CA9 | Q16790 | 5/20 | 0.59 |
| ▸ | SUCNR1 | Q9BXA5 | 4/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL910539 | 0.88 | CA1 (0.62) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL16383769 | 0.86 | CA1 (0.57) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL30521147 | 0.86 | CA1 (0.60) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL17919114 | 0.85 | MAPK1 (0.57) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL16383753 | 0.85 | MAPK1 (0.57) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL4656567 | 0.84 | S1PR1 (0.60) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL17366464 | 0.84 | CA12 (0.59) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL917117 | 0.84 | CA1 (0.54) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL17919110 | 0.84 | CA1 (0.55) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL16383779 | 0.84 | CA1 (0.57) | CA1CA2CA12CA9SUCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922073-A1 | NEW CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | Parion Sciences, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007018640-A1 | NEW CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2007-02-15 | — | — | WO | disclosed |