Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.38 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015827 | 0.96 | FAAH (0.43) | FAAHCHRNB4CHRNA3F2F10 | |
| SCHEMBL5012848 | 0.95 | FAAH (0.42) | FAAHF2F10PRSS1KMT2A | |
| SCHEMBL5014531 | 0.93 | FAAH (0.41) | FAAHF2F10PRSS1KMT2A | |
| SCHEMBL5012817 | 0.92 | FAAH (0.39) | FAAHKMT2AMAPTTRPV1 | |
| SCHEMBL5012887 | 0.90 | FAAH (0.44) | FAAHKMT2AKDM4E | |
| SCHEMBL5012959 | 0.88 | KMT2A (0.39) | FAAHKMT2AMAPTTRPV1 | |
| SCHEMBL5014386 | 0.88 | KMT2A (0.39) | FAAHKMT2AMAPTTRPV1 | |
| SCHEMBL5015689 | 0.87 | KMT2A (0.43) | FAAHKMT2AMAPTXBP1NPSR1 | |
| SCHEMBL5012693 | 0.87 | FAAH (0.36) | FAAHKMT2AMAPTTRPV1 | |
| SCHEMBL5014417 | 0.87 | TRPV1 (0.41) | FAAHF2F10PRSS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | disclosed |