Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 19/20 | 0.70 |
| ▸ | ADORA1 | P30542 | 12/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5022290 | 0.85 | ADORA2A (0.81) | ADORA2AADORA1CYP3A4KCNH2 | |
| SCHEMBL5022548 | 0.85 | ADORA2A (0.75) | ADORA2AADORA1CYP3A4KCNH2 | |
| SCHEMBL6038177 | 0.84 | ADORA2A (0.53) | ADORA2AADORA1CYP3A4KCNH2MAPT | |
| SCHEMBL5016137 | 0.82 | ADORA2A (0.59) | ADORA2AADORA1CYP3A4KCNH2 | |
| SCHEMBL8288927 | 0.80 | MAPT (0.52) | ADORA2AADORA1CYP3A4MAPT | |
| SCHEMBL28634431 | 0.72 | ADORA2A (0.66) | ADORA2AADORA1CYP3A4KCNH2 | |
| SCHEMBL5017757 | 0.71 | ADORA2A (0.77) | ADORA2AADORA1CYP3A4 | |
| SCHEMBL5022418 | 0.71 | ADORA2A (0.67) | ADORA2AADORA1CYP3A4KCNH2MAPT | |
| SCHEMBL28632439 | 0.71 | ADORA2A (0.67) | ADORA2AADORA1CYP3A4KCNH2 | |
| SCHEMBL2809359 | 0.71 | ADORA2A (0.79) | ADORA2AADORA1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058356-A1 | 2,6 Bisheteroaryl-4-Aminopyrimidines as Adenosine Receptor Antagonists | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-03-06 | — | — | US | claimed |
| US-20080058356-A1 | 2,6 Bisheteroaryl-4-Aminopyrimidines as Adenosine Receptor Antagonists | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058356-A1 | 2,6 Bisheteroaryl-4-Aminopyrimidines as Adenosine Receptor Antagonists | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058356-A1 | 2,6 Bisheteroaryl-4-Aminopyrimidines as Adenosine Receptor Antagonists | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-03-06 | — | — | US | disclosed |
| EP-1697351-A1 | 2,6-BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS | Almirall Prodesfarma AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058883-A1 | 2, 6 BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS | ALMIRALL PRODESFARMA AG (CH) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058356-A1 | 2,6 Bisheteroaryl-4-Aminopyrimidines as Adenosine Receptor Antagonists | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA1 3/4885CYP3A4 582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.