Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 18/20 | 0.59 |
| ▸ | FKBP4 | Q02790 | 2/20 | 0.59 |
| ▸ | FKBP5 | Q13451 | 2/20 | 0.59 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3675702 | 1.00 | FKBP1A (0.59) | FKBP1AFKBP4FKBP5ABCC1 | |
| SCHEMBL3675084 | 0.91 | FKBP1A (0.58) | FKBP1AFKBP4FKBP5ABCC1 | |
| SCHEMBL3675085 | 0.91 | FKBP1A (0.58) | FKBP1AFKBP4FKBP5ABCC1 | |
| SCHEMBL3673585 | 0.86 | FKBP1A (0.76) | FKBP1AFKBP4FKBP5ABCC1 | |
| SCHEMBL3673587 | 0.86 | FKBP1A (0.76) | FKBP1AFKBP4FKBP5ABCC1 | |
| SCHEMBL3675698 | 0.85 | FKBP1A (0.61) | FKBP1AFKBP4FKBP5ABCC1 | |
| SCHEMBL3679353 | 0.85 | FKBP1A (0.60) | FKBP1AFKBP4FKBP5ABCC1 | |
| SCHEMBL3679356 | 0.85 | FKBP1A (0.60) | FKBP1AFKBP4FKBP5ABCC1 | |
| SCHEMBL5017050 | 0.81 | FKBP1A (0.65) | FKBP1AFKBP4FKBP5ABCC1 | |
| SCHEMBL3676924 | 0.80 | FKBP1A (0.65) | FKBP1AFKBP4FKBP5ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1227859-B1 | NEUROPHILIN LIGANDS FOR TREATING OCULAR CONDITIONS | ALCON INC (CH) | 2006-08-09 | — | — | EP | claimed |
| EP-0754176-B1 | NOVEL CARBAMATES AND UREAS AS MODIFIERS OF MULTI-DRUG RESISTANCE | VERTEX PHARMA (US) | 2001-12-05 | — | — | EP | claimed |
| US-5780484-A | Methods for stimulating neurite growth with piperidine compounds | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1998-07-14 | — | — | US | claimed |
| US-5744485-A | INCREASE SENSITIVITY OF CELLS; CANCER | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1998-04-28 | — | — | US | claimed |
| EP-1138673-B1 | Novel carbamates and ureas as modifiers of multi-drug resistance | VERTEX PHARMA (US) | 2008-08-06 | — | — | EP | disclosed |
| EP-1666053-A1 | Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors | Vertex Pharmceuticals Incorporated (US) | 2006-06-07 | — | — | EP | disclosed |
| EP-0754176-B1 | NOVEL CARBAMATES AND UREAS AS MODIFIERS OF MULTI-DRUG RESISTANCE | VERTEX PHARMA (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-1138673-A2 | Novel carbamates and ureas as modifiers of multi-drug resistance | Vertex Pharmaceuticals Incorporated (US) | 2001-10-04 | — | — | EP | disclosed |
| US-5780484-A | Methods for stimulating neurite growth with piperidine compounds | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1998-07-14 | — | — | US | disclosed |
| US-5744485-A | INCREASE SENSITIVITY OF CELLS; CANCER | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1998-04-28 | — | — | US | disclosed |