Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 19/20 | 0.41 |
| ▸ | HTR2A | P28223 | 17/20 | 0.41 |
| ▸ | DRD3 | P35462 | 16/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023260 | 0.86 | HTR2A (0.46) | HTR2ADRD3 | |
| SCHEMBL13200953 | 0.84 | DRD2 (0.37) | DRD2HTR2ADRD3HTR1ANPC1 | |
| SCHEMBL13200945 | 0.81 | DRD2 (0.35) | DRD2HTR2ADRD3HTR1ANPC1 | |
| SCHEMBL5419748 | 0.74 | PDCD1 (0.33) | DRD2HTR2ADRD3HTR1A | |
| SCHEMBL2965067 | 0.74 | PDCD1 (0.33) | DRD2HTR2ADRD3HTR1A | |
| SCHEMBL6360107 | 0.68 | DRD2 (0.44) | DRD2HTR2AHTR1A | |
| SCHEMBL2958808 | 0.67 | HTR2A (0.42) | HTR2ADRD3 | |
| SCHEMBL13200909 | 0.67 | HTR2A (0.42) | HTR2ADRD3 | |
| SCHEMBL13201044 | 0.66 | DRD2 (0.38) | DRD2HTR2ADRD3HTR1ANPC1 | |
| SCHEMBL2958078 | 0.66 | DRD2 (0.38) | DRD2HTR2ADRD3HTR1ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1632483-B1 | HETEROCYCLIC SUBSTITUTED CARBONYL DERIVATIVES AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | AVENTIS PHARMA INC (US) | 2008-10-29 | — | — | EP | claimed |