Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.65 |
| ▸ | PRKDC | P78527 | 1/20 | 0.65 |
| ▸ | IGF1R | P08069 | 6/20 | 0.59 |
| ▸ | INSR | P06213 | 2/20 | 0.59 |
| ▸ | SRC | P12931 | 10/20 | 0.58 |
| ▸ | KDR | P35968 | 6/20 | 0.58 |
| ▸ | ABL1 | P00519 | 5/20 | 0.58 |
| ▸ | EGFR | P00533 | 5/20 | 0.58 |
| ▸ | ABL2 | P42684 | 4/20 | 0.58 |
| ▸ | LCK | P06239 | 5/20 | 0.56 |
| ▸ | TEK | Q02763 | 3/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 3/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050381 | 0.88 | IGF1R (0.72) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL7833880 | 0.86 | SRC (0.75) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL7005521 | 0.85 | LCK (0.72) | INSRSRCKDRABL1EGFR | |
| SCHEMBL2073299 | 0.85 | KDR (0.76) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL7847466 | 0.84 | SRC (0.73) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL16202367 | 0.84 | SRC (0.67) | SRCKDRABL1EGFRABL2 | |
| SCHEMBL22676745 | 0.81 | SRC (0.67) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL27381323 | 0.80 | IGF1R (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL7835124 | 0.80 | SRC (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL130425 | 0.79 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230111917-A1 | KINASE ANTAGONISTS | UNIV CALIFORNIA (US) | 2023-04-13 | — | — | US | disclosed |
| CN-101506211-B | Kinase antagonists | UNIV CALIFORNIA | 2013-05-22 | — | — | CN | disclosed |
| CN-101506211-A | Kinase antagonists | UNIV CALIFORNIA (US) | 2009-08-12 | — | — | CN | disclosed |
| EP-2004654-A2 | KINASE ANTAGONISTS | The Regents of the University of California (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007114926-A2 | KINASE ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230111917-A1 | KINASE ANTAGONISTS | MTOR, RPS6KA3, AKT3 | PIK3CD 12/4885PIK3CA 4/4885PIK3CB 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.