Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 5/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | CTSV | O60911 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5017306 | 0.99 | PDE10A (0.52) | PDE10APDGFRBPDGFRACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL6098000 | 0.88 | KDR (0.54) | PDE10ACYP1A2CYP3A4CYP2C19FLT1 | |
| SCHEMBL5025607 | 0.85 | PDE10A (0.55) | PDE10APDGFRBPDGFRAELANEKDM1A | |
| SCHEMBL29589019 | 0.82 | PDE10A (0.56) | PDE10ACYP1A2CYP3A4CYP2C19FLT1 | |
| SCHEMBL5245231 | 0.82 | PDE10A (0.56) | PDE10ACYP1A2CYP3A4CYP2C19FLT1 | |
| SCHEMBL371731 | 0.82 | KDM1A (0.52) | PDGFRBPDGFRAELANEKDM1AEGFR | |
| SCHEMBL30216650 | 0.82 | KDM1A (0.52) | PDGFRBPDGFRAELANEKDM1AEGFR | |
| SCHEMBL2062562 | 0.82 | KDM1A (0.52) | PDGFRBPDGFRAELANEKDM1AEGFR | |
| Hydrochloric Acid SCHEMBL6435868 | 0.81 | EGFR (0.51) | PDGFRBPDGFRAELANEKDM1AEGFR | |
| SCHEMBL17372578 | 0.81 | ELANE (0.55) | PDGFRBPDGFRAELANEKDM1AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111253385-B | Heterocyclic compound, preparation method and application | 遵义医科大学珠海校区 | 2023-11-24 | — | — | CN | disclosed |
| EP-1309587-B1 | CINNOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | EP | disclosed |
| EP-1309587-B1 | CINNOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | EP | disclosed |
| US-6887874-B2 | Cinnoline compounds | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| US-20030212055-A1 | Cinnoline compounds | ASTRAZENECA AB (SE) | 2003-11-13 | — | — | US | disclosed |
| EP-1309587-A1 | CINNOLINE COMPOUNDS | AstraZeneca AB (SE) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002012228-A1 | CINNOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212055-A1 | Cinnoline compounds | VEGFA, PGF, CCR7 | PDE10A 2764/4885PDGFRB 514/4885PDGFRA 730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.