Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.57 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | KDM4A | O75164 | 3/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.50 |
| ▸ | APP | P05067 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25181480 | 0.86 | HDAC1 (0.67) | HDAC1HDAC3HDAC2HDAC8NCOR2 | |
| SCHEMBL25180614 | 0.86 | HDAC1 (0.67) | HDAC1HDAC3HDAC2HDAC8NCOR2 | |
| SCHEMBL4327317 | 0.85 | HDAC1 (0.71) | HDAC1HDAC3HDAC2HDAC8NCOR2 | |
| SCHEMBL5019149 | 0.84 | HDAC3 (0.50) | HDAC1HDAC3HDAC2HDAC8NCOR2 | |
| SCHEMBL15456409 | 0.83 | HDAC1 (0.71) | HDAC1HDAC3HDAC2HDAC8NCOR2 | |
| SCHEMBL13068773 | 0.83 | HDAC3 (0.59) | HDAC1HDAC3HDAC2HDAC8NCOR2 | |
| SCHEMBL15862571 | 0.83 | HDAC3 (0.58) | HDAC1HDAC3HDAC2HDAC8NCOR2 | |
| SCHEMBL14376730 | 0.82 | BCHE (0.72) | HDAC1HDAC3HDAC2HDAC8NCOR2 | |
| SCHEMBL14376142 | 0.81 | BCHE (0.74) | HDAC1HDAC3HDAC2HDAC8NCOR2 | |
| SCHEMBL14376731 | 0.81 | BCHE (0.74) | HDAC1HDAC3HDAC2HDAC8NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178490-B2 | Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof | REMPEX PHARMACEUTICALS, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100152098-A1 | POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | MPEX PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152098-A1 | POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | ABCB11, ABCB1, SLC47A1 | HDAC1 852/4885HDAC3 1047/4885HDAC2 1977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.