Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 8/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23484495 | 1.00 | OPRL1 (0.50) | OPRL1GRM2HTR2AHTR2CHTR2B | |
| SCHEMBL434354 | 0.90 | OPRL1 (0.57) | OPRL1GRM2HTR2AHTR2CHTR2B | |
| SCHEMBL29487576 | 0.85 | KDM1A (0.47) | OPRL1ESR2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL22321256 | 0.85 | KDM1A (0.47) | OPRL1ESR2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL22321255 | 0.85 | KDM1A (0.47) | OPRL1ESR2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL436724 | 0.82 | OPRL1 (0.58) | OPRL1GRM2HTR2AHTR2CHTR2B | |
| SCHEMBL435077 | 0.82 | OPRL1 (0.54) | OPRL1GRM2HTR2AHTR2CHTR2B | |
| SCHEMBL505182 | 0.81 | OPRL1 (0.49) | OPRL1HTR2AHTR2CHTR2B | |
| SCHEMBL5019313 | 0.81 | OPRL1 (0.50) | OPRL1GRM2HTR2AHTR2CHTR2B | |
| SCHEMBL28712898 | 0.81 | OPRL1 (0.50) | OPRL1GRM2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9271967-B2 | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9271967-B2 | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-03-01 | — | — | US | disclosed |
| EP-2649069-B1 | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2015-08-26 | — | — | EP | disclosed |
| WO-2012062750-A1 | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | Janssen Pharmaceuticals, Inc. (US) | 2012-05-18 | — | — | WO | disclosed |