Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 10/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL435254 | 0.98 | OPRL1 (0.59) | OPRL1HTR2AHTR2CHTR2BPTGDR2 | |
| SCHEMBL435077 | 0.96 | OPRL1 (0.54) | OPRL1HTR2AHTR2CHTR2BPTGDR2 | |
| SCHEMBL434354 | 0.91 | OPRL1 (0.57) | OPRL1HTR2AHTR2CHTR2BCHRNB2 | |
| SCHEMBL29266754 | 0.88 | OPRL1 (0.56) | OPRL1HTR2AHTR2CHTR2BTP53 | |
| SCHEMBL11773147 | 0.83 | KDM1A (0.52) | OPRL1PTGDR2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL23484495 | 0.82 | OPRL1 (0.50) | OPRL1HTR2AHTR2CHTR2BCHRNB2 | |
| SCHEMBL5019313 | 0.82 | OPRL1 (0.50) | OPRL1HTR2AHTR2CHTR2BCHRNB2 | |
| SCHEMBL28712898 | 0.82 | OPRL1 (0.50) | OPRL1HTR2AHTR2CHTR2BCHRNB2 | |
| SCHEMBL30232333 | 0.82 | SLC6A2 (0.55) | OPRL1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5019341 | 0.82 | OPRL1 (0.50) | OPRL1HTR2AHTR2CHTR2BCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424911-B1 | POSACONAZOLE, COMPOSITION, INTERMEDIATE, PREPARATION METHOD THEREFOR, AND USES THEREOF | ZHEJIANG AUSUN PHARMACEUTICAL CO LTD (CN) | 2021-07-28 | — | — | EP | disclosed |
| EP-3424911-A1 | POSACONAZOLE, COMPOSITION, INTERMEDIATE, PREPARATION METHOD THEREFOR, AND USES THEREOF | Zhejiang Ausun Pharmaceutical Co., Ltd. (CN) | 2019-01-09 | — | — | EP | disclosed |
| EP-2595984-A1 | MICROBICIDES | Syngenta Participations AG (CH) | 2013-05-29 | — | — | EP | disclosed |
| EP-2595985-A1 | ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES | Syngenta Participations AG (CH) | 2013-05-29 | — | — | EP | disclosed |
| EP-1940401-B1 | ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2012-07-11 | — | — | EP | disclosed |
| WO-2012010568-A1 | MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012010567-A1 | ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-01-26 | — | — | WO | disclosed |
| WO-2008039418-A2 | ACYLATED PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-04-03 | — | — | WO | disclosed |