Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31595597 | 0.82 | HTR2A (0.50) | HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5019354 | 0.82 | HTR2A (0.50) | HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9825823 | 0.80 | CYP19A1 (0.39) | HTR2ASLC6A2SLC6A4SLC6A3HTR2B | |
| SCHEMBL506553 | 0.79 | PDPK1 (0.46) | HTR2ALTB4RLTB4R2SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL30799506 | 0.77 | PDPK1 (0.44) | HTR2ASLC6A2SLC6A4SLC6A3CYP2D6 | |
| Hydrochloric Acid SCHEMBL10558181 | 0.75 | LTB4R (0.40) | HTR2ALTB4RLTB4R2SLC6A2SLC6A4 | |
| SCHEMBL27198041 | 0.75 | TRPV1 (0.39) | HTR2ALTB4RLTB4R2SLC6A4HTR2B | |
| SCHEMBL31040814 | 0.75 | TRPV1 (0.39) | HTR2ALTB4RLTB4R2SLC6A4HTR2B | |
| SCHEMBL24915634 | 0.75 | LTB4R (0.45) | HTR2ALTB4RLTB4R2SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL31137332 | 0.74 | TRPV1 (0.39) | LTB4RLTB4R2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9271967-B2 | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-03-01 | — | — | US | disclosed |
| WO-2012062750-A1 | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | Janssen Pharmaceuticals, Inc. (US) | 2012-05-18 | — | — | WO | disclosed |
| US-4932998-A | LOW PHYTOTOXICITY FOR PADDY RICE PLANTS | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0283522-A1 | TRIAZINE DERIVATIVE, PRODUCTION THEREOF, AND HERBICIDE CONTAINING SAME AS EFFECTIVE INGREDIENT | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1988-09-28 | — | — | EP | disclosed |