Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4569434 | 0.87 | PIK3CG (0.41) | PIK3CGLRRK2PDPK1RPS6KB1PIK3CD | |
| SCHEMBL4569449 | 0.84 | PIK3CG (0.45) | PIK3CGLRRK2PDPK1RPS6KB1PIK3CD | |
| SCHEMBL4569409 | 0.80 | IRAK4 (0.41) | PIK3CGLRRK2PDPK1PIK3CDIRAK1 | |
| SCHEMBL4569421 | 0.78 | PIK3CG (0.44) | PIK3CGLRRK2PDPK1RPS6KB1PIK3CD | |
| SCHEMBL4569441 | 0.78 | PIK3CG (0.42) | PIK3CGLRRK2PDPK1RPS6KB1PIK3CD | |
| SCHEMBL17913949 | 0.77 | SOS1 (0.39) | PIK3CGPDPK1RPS6KB1PIK3CDPIK3R1 | |
| SCHEMBL4569395 | 0.77 | LRRK2 (0.41) | PIK3CGLRRK2PDPK1RPS6KB1PIK3CD | |
| SCHEMBL4569435 | 0.75 | PIK3CG (0.39) | PIK3CGPDPK1RPS6KB1PIK3CDPIK3CA | |
| SCHEMBL4569404 | 0.74 | PIK3CG (0.38) | PIK3CGLRRK2PDPK1RPS6KB1PIK3CD | |
| SCHEMBL4569398 | 0.74 | MEN1 (0.39) | PIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064973-A2 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |