SCHEMBL5019569

SCHEMBL5019569

O=C(Cc1cc(CC(=O)ON2C(=O)CCC2=O)cc(CC(=O)ON2C(=O)CCC2=O)c1)ON1C(=O)CCC1=O

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.41
MAPK1 P28482 2/20 0.40
HPGD P15428 1/20 0.40
HSP90AB1 P08238 1/20 0.37
ALDH1A1 P00352 1/20 0.35
PKM P14618 1/20 0.35
MGLL Q99685 4/20 0.34
PSMB8 P28062 2/20 0.33
PSMB5 P28074 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
PAM P19021 1/20 0.32
ALOX12 P18054 1/20 0.32
PARL Q9H300 1/20 0.32
ADORA3 P0DMS8 1/20 0.31
ADORA2A P29274 1/20 0.31
ADORA2B P29275 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13404896 0.93 KMT2A (0.40) KMT2AMAPK1HPGDHSP90AB1ALDH1A1
SCHEMBL19658177 0.89 KMT2A (0.50) KMT2AMAPK1HPGDALDH1A1PKM
SCHEMBL499428 0.88 KMT2A (0.46) KMT2AMAPK1HPGDALDH1A1PKM
SCHEMBL5030088 0.84 KMT2A (0.33) KMT2AMAPK1HPGDHSP90AB1ALOX12
SCHEMBL20143534 0.83 KMT2A (0.33) KMT2AMAPK1HPGDPSMB8CYP1A2
SCHEMBL2450503 0.83 KMT2A (0.57) KMT2AMAPK1HPGDALDH1A1PKM
SCHEMBL5852228 0.82 CA2 (0.46) KMT2AMAPK1HPGDALDH1A1
SCHEMBL20278322 0.81 HSP90AB1 (0.45) KMT2AHPGDHSP90AB1ALDH1A1PKM
SCHEMBL17356716 0.80 KMT2A (0.41) KMT2AMAPK1HPGDALDH1A1MGLL
SCHEMBL15896085 0.80 KMT2A (0.44) KMT2AMAPK1HPGDALDH1A1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9970055-B2 Method of nucleotide detection ILLUMINA CAMBRIDGE LIMITED (GB) 2018-05-15 US disclosed
US-20160208324-A1 METHOD OF NUCLEOTIDE DETECTION ILLUMINA CAMBRIDGE LIMITED (GB) 2016-07-21 US disclosed
US-20160208324-A1 METHOD OF NUCLEOTIDE DETECTION ILLUMINA CAMBRIDGE LIMITED (GB) 2016-07-21 US disclosed
US-9303290-B2 Method of nucleotide detection ILLUMINA CAMBRIDGE LIMITED 2016-04-05 US disclosed
US-9303290-B2 Method of nucleotide detection ILLUMINA CAMBRIDGE LIMITED 2016-04-05 US disclosed
US-9217178-B2 Method of nucleotide detection ILLUMINA CAMBRIDGE LIMITED (GB) 2015-12-22 US disclosed
US-9217178-B2 Method of nucleotide detection ILLUMINA CAMBRIDGE LIMITED (GB) 2015-12-22 US disclosed
US-20140378323-A1 METHOD OF NUCLEOTIDE DETECTION ILLUMINA CAMBRIDGE LIMITED (GB) 2014-12-25 US disclosed
US-20140378323-A1 METHOD OF NUCLEOTIDE DETECTION ILLUMINA CAMBRIDGE LIMITED (GB) 2014-12-25 US disclosed
US-8168388-B2 Preparation of nucleic acid templates for solid phase amplification ILLUMINA CAMBRIDGE LTD (GB) 2012-05-01 US disclosed
US-8168388-B2 Preparation of nucleic acid templates for solid phase amplification ILLUMINA CAMBRIDGE LTD (GB) 2012-05-01 US disclosed
US-7704543-B2 Conversion of amine- to carboxyl groups on solid surfaces ILLUMINA CAMBRIDGE LIMITED (GB) 2010-04-27 US disclosed
US-20100041561-A1 Preparation of Nucleic Acid Templates for Solid Phase Amplification ILLUMINA CAMBRIDGE LIMITED (GB) 2010-02-18 US disclosed
US-20100041561-A1 Preparation of Nucleic Acid Templates for Solid Phase Amplification ILLUMINA CAMBRIDGE LIMITED (GB) 2010-02-18 US disclosed
US-20080280773-A1 Method of Nucleotide Detection ILLUMINA CAMBRIDGE LIMITED (GB) 2008-11-13 US disclosed
US-20080280773-A1 Method of Nucleotide Detection ILLUMINA CAMBRIDGE LIMITED (GB) 2008-11-13 US disclosed
US-20070042109-A1 Conversion of amine- to carboxyl groups on solid surfaces ILLUMINA CAMBRIDGE LIMITED (GB) 2007-02-22 US disclosed
US-20070042109-A1 Conversion of amine- to carboxyl groups on solid surfaces ILLUMINA CAMBRIDGE LIMITED (GB) 2007-02-22 US disclosed