Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 5/20 | 0.42 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR1F | P30939 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.36 |
| ▸ | RORC | P51449 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019620 | 0.94 | IL2 (0.41) | IL2STIM1ORAI1ORAI2P2RX7 | |
| SCHEMBL5019755 | 0.83 | IL2 (0.40) | IL2HTR1FMEN1NPC1RAB9A | |
| SCHEMBL5019743 | 0.83 | PTPN11 (0.33) | IL2NPC1RAB9A | |
| SCHEMBL1781037 | 0.82 | STIM1 (0.44) | IL2STIM1ORAI1ORAI2L3MBTL1 | |
| SCHEMBL3830406 | 0.81 | STIM1 (0.44) | IL2STIM1ORAI1ORAI2L3MBTL1 | |
| SCHEMBL7920820 | 0.80 | STIM1 (0.44) | IL2STIM1ORAI1ORAI2L3MBTL1 | |
| SCHEMBL3824488 | 0.80 | IL2 (0.42) | IL2STIM1ORAI1ORAI2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL616904 | 0.80 | STIM1 (0.44) | IL2STIM1ORAI1ORAI2L3MBTL1 | |
| SCHEMBL4999794 | 0.80 | IL2 (0.46) | IL2STIM1ORAI1ORAI2L3MBTL1 | |
| SCHEMBL1781633 | 0.79 | IL2 (0.43) | IL2STIM1ORAI1ORAI2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |