Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | CCR1 | P32246 | 3/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.34 |
| ▸ | RBP4 | P02753 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4566187 | 0.92 | GRM2 (0.53) | GRM2SLC6A3 | |
| SCHEMBL5020035 | 0.84 | GRM2 (0.41) | GRM2DRD4CCR1MALT1KMT2A | |
| SCHEMBL4566385 | 0.82 | GRM2 (0.50) | GRM2KMT2ANPSR1 | |
| SCHEMBL16755854 | 0.81 | GRM2 (0.56) | GRM2SLC6A3CCR1PTGDR2 | |
| SCHEMBL16755901 | 0.76 | GRM2 (0.56) | GRM2TSHR | |
| SCHEMBL16755876 | 0.74 | CHRM4 (0.41) | GRM2MALT1RBP4 | |
| SCHEMBL5020038 | 0.72 | GRM2 (0.54) | GRM2SLC6A3HTR2A | |
| SCHEMBL19625664 | 0.71 | OPRM1 (0.44) | GRM2DRD4DRD2HTR2A | |
| SCHEMBL16755836 | 0.71 | GRM2 (0.56) | GRM2KMT2ANPSR1 | |
| SCHEMBL16755743 | 0.70 | GRM2 (0.53) | GRM2RBP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012062752-A1 | RADIOLABELLED mGLuR2 PET LIGANDS | Janssen Pharmaceuticals, Inc. (US) | 2012-05-18 | — | — | WO | disclosed |